The following techniques are not available as diagnostic tests but have been used in research settings to evaluate the presence or absence of dense granules in blood platelets.
The dense granules of platelets contain a number of chemicals including serotonin. Due to the absence of dense granules in HPS platelets the level of serotonin found is typically extremely low. This property has been used as an indirect measure of the presence \ absence of dense granules.
Platelet Serotonin reference ranges:
Given the near absence of Serotonin it can be used as a marker for HPS. Commercially available ELISA kits can be used on a research basis to measure the level of serotonin present in PRP. None, however, are currently licensed \ approved as a diagnostic test for HPS.
Ceroid Lipofucin is a yellow autofluorescent, amorphous lipid-